Package: dfpk
Type: Package
Title: A Bayesian Dose-Finding Design using Pharmacokinetics(PK) for
        Phase I Clinical Trials
Version: 1.0
Date: 2016-07-05
Author: Artemis Toumazi <artemis.toumazi@inserm.fr> , Moreno Ursino <moreno.ursino@inserm.fr> and Sarah Zohar <sarah.zohar@inserm.fr>
Maintainer: Artemis Toumazi <artemis.toumazi@inserm.fr>
Description: Includes methods involving PK measures in the dose allocation process during a Phase I clinical trials. These methods enter PK in the dose finding designs in different ways, including covariates models, dependent variable or hierarchical models. This package provides functions to generate scenarios, and to run simulations which their objective is to determine the maximum tolerated dose (MTD) and to investigate PK of a drug or a combination of drugs.
License: GPL (>= 3)
Depends: R (>= 3.0.2), Rcpp (>= 0.11.0)
Imports: rstan (>= 2.8.1), ggplot2 (>= 2.0.0), dfcrm, methods, stats,
        graphics, grDevices
LinkingTo: StanHeaders (>= 2.8.0), rstan (>= 2.8.1), BH (>= 1.58.0),
        Rcpp (>= 0.11.0), RcppEigen
RcppModules: stan_fit4logit_cov2_mod, stan_fit4logit_reg_dtox_mod,
        stan_fit4logit_reg_pkpop_mod, stan_fit4logit_reg_mod,
        stan_fit4reg_auc2_mod
LazyData: true
NeedsCompilation: yes
URL: http://github.com/artemis-toumazi/dfpk
BugReports: http://github.com/artemis-toumazi/dfpk/issues
RoxygenNote: 5.0.1
Packaged: 2016-08-09 19:31:31 UTC; Artemis
Repository: CRAN
Date/Publication: 2016-08-10 10:06:56
Built: R 3.3.2; x86_64-w64-mingw32; 2016-12-02 04:20:09 UTC; windows
Archs: i386, x64
